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Neurochem Res 33:194203 Valdecantos MP, Prez-Matute P, Gonzlez-Muniesa P, Prieto-Hontoria PL, Moreno-Aliaga MJ, Martnez JA (2012) Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3

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Compared to oral administration, rectal delivery achieves higher effective drug exposure at the lesion site while reducing systemic distribution, thus lowering the risk of potential systemic side effects