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This regulatory mechanism explains the so-called arginine paradox, which refers to the phenomenon where extracellular L-arginine availability influences NO production despite the saturation of NOS enzymes with intracellular arginine

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Among upstream regulators of ferroptosis in IBD, hypoxia-inducible factors (HIFs) occupy a unique position by integrating hypoxic stress, iron homeostasis, and inflammatory signaling, thereby setting the threshold at which epithelial ferroptosis is triggered

iii) patients treated with GSH were directly compared with a non-GSH or placebo group

By restoring B12 levels, many individuals experience improved mood, reduced feelings of anxiety or depression, and enhanced mental clarity