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While agonist peptides based on either scaffold are potent in rat obesity models 2,10,11,12,13 , only a transient weight loss effect is observed with sCT in mouse diet-induced obesity (DIO) models 14 , indicating that there may be distinctions in the mode of action of individual dual agonists

Symptoms may depend on the age and genetic disposition of the individual, and also the length and severity of deficiency

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3c), underscoring rapid onset of action

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It is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist