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Acknowledgements This work is supported by the National Natural Science Foundation of China (22172008, L.F

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Baseline WOMAC pain score: approximately 6 out of 20 Reduction in active treatment arms: approximately 4.5 points , representing a ~76% decrease from baseline Complete freedom from knee pain at week 68: reported by roughly 1 in 8 patients (12.5%) receiving retatrutide, compared to just 4.2% in the placebo group A 76% reduction in pain scores is extraordinary approaching the range typically seen after total knee replacement surgery

Glutamine supplementation has shown promise in alleviating the severity of cachexia by improving the nutritional status and functional capacity of cancer patients undergoing intensive treatment regimens [81]

Unlike other administration methods, the TF model overcomes the innate aversion to alcohol often observed in rodents, ensuring better control over the alcohol intake of each experimental animal and reducing experimental errors

Speaking of GLP-1 related issues