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Letrozole works by inhibiting aromatase, the enzyme needed for conversion of androgens to estrogens

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Hepatotoxicity Warn patients and guardians that nausea, vomiting, abdominal pain, anorexia, diarrhea, asthenia, and/or jaundice can be symptoms of hepatotoxicity and, therefore, require further medical evaluation promptly [seeWarnings and Precautions (5.1)]