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Rather than engineer a new single molecule, Novo Nordisk paired an existing approved GLP-1 drug (semaglutide 2.4 mg) with a novel long-acting amylin analogue (cagrilintide)

Currently available GLP-1 receptor agonists in the United States include exenatide (Byetta, Bydureon BCise), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), semaglutide (Ozempic, Wegovy, Rybelsus), and tirzepatide (Mounjaro, Zepbound), though tirzepatide is technically a dual GIP/GLP-1 receptor agonist

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However, results vary depending on adherence and baseline metabolic function

doi: 10.1152/ajpregu.00068.2018