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In the phase 3 SLIMMER trial published in The Lancet Diabetes & Endocrinology last year, ecnoglutide achieved weight loss of 15.1% at 48 weeks, with no evidence of a plateauing of effect, along with improvements in waist circumference, blood pressure, lipid profile, HbA1c, fasting glucose, and insulin levels

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Takahashi et al

Previously, a randomized controlled trial demonstrated that the efficacy of PEG-Loxenatide in patients with mild-to-moderate DKD was comparable to that of the first-line SGLT2 inhibitors, such as Dapagliflozin, with an additional benefit of improved lipid levels [5]

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