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When initiating Rybelsus in patients already taking sulfonylureas or insulin, a reduction in the dose of these medications should be considered to reduce the risk of hypoglycaemia

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10.1016/j.bbrc.2016.11.017 [DOI] [PubMed] [Google Scholar] Suzuki T., Heaney L

Nonetheless, the conclusions from these different studies raise the question of which, if any, redox couples are directly leading to cell death, i.e., is oxidation of thioredoxins or glutathione important, or are both perhaps simply markers of NADPH depletion

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This is not a rare scenario