Due to the fact that amlodipine exhibits anti-glycation activity, its effect in diseases associated with hyperglycemia and increased oxidative stress should be investigated in both type 1 and type 2 diabetes, diabetic nephropathy, diabetic retinopathy, atherosclerosis, and hypertension 59
Thus, we have demonstrated that GSH-targeted therapy selectively kills PC cells in an oxidative stress-dependent manner and that the differences in basal ROS level and antioxidant scavenging capacity induced by stratified expression of VRK2 can well account for the heterogeneous sensitivity to GSH inhibition
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