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Risk level depends on the medication type, dose, health history, current medications, and whether appropriate monitoring is in place

It must be noted, however, that increased GFAP expression and GFAP-positive astrocytic profiles are not always associated with pathology

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570,571 For example, based on the unique mechanism of action of ASOs, the main safety issues are severe hepatotoxicity and nephrotoxicity caused by drug accumulation

China 142, 92102

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