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Mills BJ, Weiss MM, Lang CA, Liu MC, Ziegler C (2000) Blood glutathione and cysteine changes in cardiovascular disease

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Standard titration spans 46 weeks from initiation to therapeutic dose

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AC system activation generates an increase of the intracellular secondary messenger, cyclic adenosine monophosphate (cAMP), through the conversion of adenosine triphosphate, which then results in the activation of protein kinase A (PKA) and exchange protein activated by cAMP (Epac) [32,33,34,35]