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These findings actively challenge the rationale for meldonium as a performance-enhancing agent and raise unresolved concerns about its psychological tolerability, possible interference with physiological adaptation, and long-term safety profile ( In light of these methodological limitations, it is premature to definitively classify meldonium as either an effective or ineffective doping agent

Anticipate mixed results because of genetic and physiological variability

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A full matrix of evolutionary distances was calculated, and the phylogenetic tree representation was generated from this distance matrix, using the programmes FITCH and DRAWTREE, as part of the PHYLIP package 58

J Neurol Neurosurg Psychiatry 87:295301 Ishimoto T, Nakamichi N, Hosotani H, Masuo Y, Sugiura T, Kato Y (2014) Organic cation transporter-mediated ergothioneine uptake in mouse neural progenitor cells suppresses proliferation and promotes differentiation into neurons