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In OA, fibroblast-like synoviocytes and synovial macrophages acquire a pro-inflammatory phenotype, secreting high levels of cytokines and chemokines and prostaglandins, together with matrix-degrading enzymes and nitric oxide

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The acylcarnitine mix solution and the Fatty acid-BSA conjugate were combined to make the final treatment solution with a final concentration of 5 M TMAO, 10 M L-carnitine, 10 nM C6:0-CAR, 10 nM C12:0-CAR, 1 mM UC13-C16:0 and 20 M DHA

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Some patients may take it for 6 to 12 months, reach a healthy and stable weight, and work with their provider on tapering down or transitioning off

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