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19 For example, the ADH1B*2 allele, found in high frequency in Asians and a lower frequency in European, African, and Jewish populations, appears to have a protective effect against alcohol dependence because the mutation increases the rapid oxidation of ethanol, thus forming the toxic acetaldehyde intermediate

doi: 10.3390/jpm12050673, 188

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The confounders that were adjusted for included child age and sex, mothers education, locality, wealth quintile, household size, type of cooking fuel, passive smoking indicator, along with cluster effects at PSU level