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2.3.2.3 Systemic vasculitis Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) are associated with antineutrophil cytoplasmic antibodies (ANCA)

4 Additionally, fat cell-derived hormones called adipokines leptin and adiponectin changed consistent with better metabolic health

Finan B, ..., Tschp MH

Mechanism: VEGF pathway modulation promoting physiological angiogenesis and endothelial protection, anti-inflammatory effects reducing vascular damage

Chronic joint/tendon issues: 68 weeks may be appropriate

Most long-term users appear to have concluded that theoretical risk does not outweigh demonstrated benefits based on their personal experience