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After adolescence, the blood vessels that once supplied nutrients to the disc largely disappear

In dendrites of cortical pyramidal neurons lacking a novel MAM protein PDZ domain-containing protein 8, a significant fraction of Ca 2+ released from the ER during synaptic stimulation accumulates in the cytosol and elevates the local dendritic Ca 2+ levels

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This substantial creatine content also supports body composition goals when combined with regular exercise

However, individual responses vary significantly