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Schools, healthcare providers, and specialist referral pathways recognize it without additional validation

The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females

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In addition to free pantothenic acid, these include: Coenzyme A: A common source of this vitamin in foods

PMCID: PMC6543499 )