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In follow-up of these studies, it was shown that Mito-TEMPO, which is highly effective in protecting against APAP toxicity [29], did not reduce LPO or liver injury in animals co-treated with APAP and Fe 2+ [82]

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Thus, the authors demonstrate the presence of GSTM1-1 in liver and conclude that the alkylation and potential irreversible inactivation of this isoform in vivo could contribute to an understanding of the hepatotoxicity associated with zileuton [55]