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In the N171-82Q transgenic mouse model, exendin-4 treatment improved motor function, prolonged survival, and reduced mutant huntingtin aggregation in the brain

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Although various PHGDH inhibitors have been developed (including ketothioamide, BI-4924, indoleamide, piperazine-1-thiourea inhibitors, and allosteric inhibitors) and have demonstrated anti-tumor effects, no PHGDH inhibitors have been approved by the FDA for clinical application, as a result of challenges such as metabolic compensation, drug selectivity, resistance, toxicity, and the complexity of drug development [165, 166]

By understanding the risks, staying hydrated, and working closely with a provider to personalize your dosage, you can effectively manage your weight without compromising your gut health

References: Lyczak, J

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