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1 A 2011 comparative effectiveness review showed that metformin, second-generation sulfonylureas, thiazolidinediones, and repaglinide (Prandin) lowered A1C levels by about 1% when used as monotherapy and that combination therapies showed an additive effect on A1C levels

doi: 10.1136/annrheumdis-2014-207169 43

doi: 10.1016/j.aller.2013.03.004

From our blood system carrying essential glucose, oxygen and nutrients to cells, to the kidneys getting rid of waste products we no longer want, fluid in the body is vital to allow these to occur

In the short term, these outcomes appear similar to those achieved through bariatric/metabolic surgical procedures

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