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Additionally, new or worsening constipation accompanied by unexplained weight loss (beyond expected therapeutic weight reduction), persistent changes in stool caliber, or alternating constipation and diarrhea warrants evaluation to exclude structural or neoplastic causes, particularly in patients age 45 or older or those with family history of colorectal cancer
Finally, the area of lipid deposition was quantified with Image-pro plus 6.0 software (Media Cybermetrics, Rockville, MD, USA), thereby calculating the percentage of area of lipid deposition
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The drug might work because it affects the part of the brain tied to feeling reward
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