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It has been found to be effective in achieving clinically significant weight loss, with about four patients needing to be treated with naltrexone/bupropion instead of placebo for one additional patient to achieve at least a 5% weight loss

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The prescribing information recommends using a non-oral contraceptive method or adding a barrier method for 4 weeks after treatment initiation and for 4 weeks after each dose escalation

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ScienceDirect , World Journal of Gastroenterology , vol