Physiol Rev 95(2):513548 Scheen AJ (2008) New therapeutic approaches in type 2 diabetes
Safety & Real-World Considerations - GI side effects remain the most common limitation - Early-stage pancreatitis risk requires monitoring - Long-term adherence is criticalbut not always achieved - Access and cost continue to be major barriers Bottom line: GLP-1 therapies are evolving from diabetes drugs into foundational tools for managing the entire cardiometabolic continuum
If anxiety is strong enough that you delay doses, feel panicky, or cannot complete the injection, talk with your healthcare provider
Rapidly acting drugs could save lives, especially in the suicidal patient population
GLP-1 receptor activation primarily occurs in the brain's hypothalamic regions, directly suppressing appetite and food-seeking behaviors
164 de la Monte et al suggested that in AD, a triangulated Mal-signaling network initiated by the brains insulin/IGF resistance is transmitted through the ceramides and ER stress homeostasis disorder, which in turn promotes IR