Nagai H, Matsumaru K, Feng G, Kaplowitz N
That calcium signal is necessary for normal brain function, but excessive NMDAR activity creates excitatory pressure
Glutathione Depletion: A Modern Epidemic Glutathione levels decline with age - typically by 1015% per decade after age 20 - and are further depleted by: *Chronic illness and autoimmune conditions *Environmental toxin exposure (heavy metals, pesticides) *Poor nutrition (insufficient cysteine, glycine, glutamate precursors) *Chronic psychological stress *Alcohol consumption *Certain medications (acetaminophen, chemotherapy agents) *Intense physical exercise without adequate recovery Given that thyroid disease prevalence increases with age and is associated with chronic immune activation, the parallel decline in glutathione levels is not coincidental - it is mechanistically significant
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Increase in activity during calorie restriction requires Sirt1
Defining the role of Parasutterella, a previously uncharacterized member of the core gut microbiota (in Eng)