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Arterial blood gas showed metabolic acidosis ( Table 1 )

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The differential equation for cytosolic GSH is: The first term is the synthesis of GSH from glycine and glutamyl-cysteine

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GSTP1 conjugates and detoxifies ethacrynic acid (Ahokas et al, 1984), which was significantly more toxic to GSTP1 null cells (1.3-fold increase in IC 50 , P =0.004, Figure 2A)

Upon ligand binding, conformational changes occur in the N-terminal ECD, leading to the activation of intracellular signaling cascades