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The decrease of glutathione levels has been detected in several AD mouse models including triple-transgenic (3X-AD-Tg) and APP/PS1 mouse 61,62

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Mass spectrometry analysis revealed a threefold increase in markers of neuronal membrane lipid peroxidation in Bmal1 knockout mice, reflecting heightened neuronal oxidative damage [179]

In Parkinsons disease, there becomes an issue with oxidative damage in the brain as well as lower levels of glutathione

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