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In situ hybridization (ISH) studies have revealed that GLP-1R mRNA is also expressed in the human brain PVH, with its expression significantly reduced in T2DM patients compared to controls, potentially contributing to homeostatic imbalance [90]

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While vitamin B12 is important for general health, there isnt direct evidence linking it specifically to increased longevity

10.1016/s1050-1738(99)00020-21 Trends Cardiovasc Med

Albani D, Polito L, Signorini A, Forloni G