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As for the culture environment in vitro, where only AML cells are present, orid-liposome-MAL can non-competitively enter all AML cells, causing REDOX imbalance and exerting its anti-tumor effects

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Additionally, transferrin-conjugated nanoparticles delivering doxorubicin showed cytotoxicity in myeloid leukemia cells in vitro and in vivo (190, 191)

doi: 10.1042/CS20090513 125 HiraseT.KawashimaS.WongE

Consistent with the loss-of-function effects of genetic variations in human CAMKK2 , mice lacking Camkk2 display behavioural traits similar to those frequently observed in bipolar disorder [33]

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