Helakari H et al (2022) Human NREM sleep promotes brain-wide vasomotor and respiratory pulsations
A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients
Individuals who may benefit include those experiencing fatigue associated with oxidative stress or inadequate cellular recovery, people with compromised liver function or high toxic exposure, those dealing with chronic inflammation or frequent illness, athletes seeking to support faster recovery from intense training, and individuals with age-related concerns where declining glutathione synthesis is a documented phenomenon
Some people prefer using warm water (not boiling) to make it more like a tonic
This represents the best-quality clinical evidence for DSIP, though the sample size was small Multi-species animal data -- DSIP has demonstrated sleep-promoting effects in rabbits, mice, rats, cats, and humans Stress modulation -- DSIP suppresses stress-induced cortisol and ACTH rises, potentially relevant for stress-related insomnia Opioid and alcohol withdrawal -- small studies explored DSIP as an adjunct in withdrawal management 2024 fusion peptide study -- published in Frontiers in Pharmacology, research on DSIP-BBB fusion peptides in insomnia mouse models represents renewed interest in DSIP Important limitations of DSIP's clinical evidence: Most studies are from the 1980s-1990s, conducted before modern polysomnography and sleep study methodology were standardized Sample sizes are consistently small Results are inconsistent across studies -- some show clear sleep effects while others do not No large-scale, placebo-controlled RCTs have been conducted Publication bias (positive results more likely published) may inflate the apparent evidence Side Effects Comparison# Cortistatin Side Effects# No human safety data exists
Ipamorelin produces no significant ACTH or cortisol elevation even at 200+ fold its GH ED
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