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Al-Dujaili EA, Ashmore S, Tsang C

Cisplatin, a potent antitumor agent widely employed in the chemotherapy of various solid malignancies, is notorious for severe side effects such as nausea, vomiting, cognition loss, neurotoxicity, and neuropathy

For example, the redox activitiy of p66Shc within mitochondria has been shown to generate H 2 O 2 in the absence of superoxide through oxidation of cytochrome c ( 2 O 2

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Fragments per kilobase of exon per million reads mapped were calculated for each gene using Cufflinks, and read counts for each gene were obtained using htseq-count