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Tolerance development : Effects diminish over time, requiring higher doses

The diagnostic criteria for hypertension were an average systolic blood pressure (SBP) 140 mmHg or diastolic blood pressure (DBP) 90 mmHg (measured three times at 5-min intervals), or 24-h SBP 130 mmHg or 24-h DBP 80 mmHg, or a history of hypertension with treatment using antihypertensive medications (12)

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These results inform clinical decision-making and expand knowledge of incretin-based therapys broader health benefits

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Although long-acting glucagon-like peptide-1 (GLP-1) analogues are now in routine use for diabetes and are now being utilised for obesity per se , the need for ever better treatments has driven the development of co-agonists, with the theoretical advantages of improved efficacy by targeting multiple pathways and reduced adverse effects