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Furthermore, through epigenetic mechanismsspecifically the acetylation of histonesALCAR can upregulate specific receptors like metabotropic glutamate 2 (mGlu2), a pathway that stimulates neurogenesis, enhances synaptic plasticity, and has been strongly tied to the compound's clinical antidepressant effects
These symptoms typically emerge during dose escalation and often diminish over several weeks as physiological adaptation occurs
The boxes represent the quartiles of the data while the whiskers represent 1.5 times the interquartile range