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One 72-week trial with a 20-week escalation found these results: 5 milligrams weekly: 15% weight reduction 10 milligrams weekly: 19.5% weight reduction 15 milligrams weekly: 20.9% weight reduction Further tirzepatide trials have been completed and show that with low-calorie diets and regular exercise, tirzepatide users can expect a total weight reduction of up to 26%

Accessed on August 29, 2023 at Mayo Clinic

Skipping doses or varying the routine too much may reduce the benefits or increase the chance of side effects like nausea or bloating

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Insulin resistance often worsens, and inflammation rises

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