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[DOI] [PubMed] [Google Scholar] 73.Fu Y, Zhou YJ, Lu SC, Chen AP

This structural damage causes further mitochondrial failure and even more ROS leakage, creating a continuous "doom loop" of profound energy depletion, systemic inflammation, and the hallmark symptom of post-exertional malaise (PEM)

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However, the larger ACT trial (n=2,308) did not confirm this benefit (ACT Investigators, Circulation, 2011) [68]

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