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However, the extract produced a significant 15% reduction in TMAO response in female participants of premenopausal age and male participants ( n = 13), indicating potential sex-dependent cardiovascular benefits from polyphenol interventions targeting the gut microbiome-TMAO pathway

Aging is associated with a progressive decline in mitochondrial function, characterized by reduced mitochondrial biogenesis, increased oxidative damage, and impaired mitochondrial dynamics [31]

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It is found in all living cells and consists of two nucleotides joined through their phosphate groups