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Moreover, it has been proposed that 4-HNE can induce cell death by modulating several transcription factors, such as Nrf2 and peroxisome proliferator-activated receptors (PPARs), as well as other signaling pathways, such as cell-cycle regulators and caspases [57]

In conclusion, ETC dysfunction is a common feature in PD, secondary to various pathomechanisms

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It may also cause diarrhoea, dizziness, headaches, and hot flushes