Xiaowei Lei, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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Interestingly, some PAHs, such as benzo(a)pyrene, have been reported to induce necrosis through activation of PARP-1 (Lin et al., 2008), whereas nicotine has been reported to down-regulate the expression of PARP-1 (Lu et al., 2017), reinforcing the hypothesis that, even when present in lower doses compared to tobacco smoke, PAHs in HnB mainstream smoke can contribute to testicular toxicity
10.1016/j.jbbm.2005.10.003 J
Studies of psoriasis patients undergoing Dead Sea climatotherapy have reported impressive results: high response rate, long periods of remission, and partial to complete plaque clearance (Kazandjieva 2008)