The clearest signal comes straight from FDA prescribing information for semaglutide products, which notes that there have been postmarketing reports of acute kidney injury, in some cases requiring hemodialysis
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2.1.2.2 Regulatory approvals - Expedite the review process for pediatric indications of novel anti-obesity pharmacotherapies

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J Neurosci 36(23):61656174 Jander S, Schroeter M, Peters O, Witte OW, Stoll G (2001) Cortical spreading depression induces proinflammatory cytokine gene expression in the rat brain