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They found that, indeed, there was a modest beneficial effect on kidney function even in people without kidney disease, and a larger beneficial effect in slowing rate of kidney function loss in people with kidney disease, explains Shuchi Anand, MD, MS, an associate professor of medicine (nephrology) at Stanford Medicine

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doi: 10.1186/s40795-021-00485-5 231

Furthermore, the concurrent addition of ICG-001 negated the amelioration of GLP-1 secretion by recovering NAD + levels, suggesting that Wnt signaling regulates GLP-1 secretion from L cells as a downstream mediator of NAD + biosynthesis

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