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Ethics declarations Competing interests The authors declare the following competing interests: T.M

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Overall, across the two repeat experiments for Cagri and CagriBB bound to the CTR, the conformational equilibrium between the bypass vs CT-like state was similar, suggesting that the salt bridge/ionic lock is sufficient to preferentially stabilize the bypass conformation at CTR (Supplementary Fig

Nasal application: Hold the subject's head gently but firmly to stabilize it

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