Although rare, adverse effects of high-dose vitamin B12 have been reported, including allergic reactions such as fever, rash, itching, hot flushes, dizziness, and nausea, across all cobalamin forms and administration routes ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits
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It is not approved for human or veterinary use by the FDA or any other regulatory agency
Those who cannot absorb vitamin B12 through their gastrointestinal tract are typically prescribed B12 injections
Research has demonstrated no significant changes in fasting glucose or insulin sensitivity in subjects using the peptide