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GHK also had no apparent cytotoxic effects on MSC in culture over a wide range of concentrations [ 44 ]
Since the 5 -reductase-1 activity is 3 to 4 times greater in malignant than in benign prostate tissues, while the 5 -reductase-2 activity is similar in these 2 diseases 91 , whether inhibition of both isozymes by combination of specific type 1 and type 2 inhibitor or using dual inhibitor is more effective in the prevention and therapy of prostate cancer is an interesting strategy and remains to be determined
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