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2c), which resulted in a significant enhancement of rotenone-induced O 2 (Fig

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Expression of micronutrient deficiencies in ASD Frequently overlooked are the data demonstrating that endogenous aldehydes induce localized, intracellular deficiencies in a subset of micronutrients, which either initiate oxidative stress (multiple sulfur-containing antioxidants, Zn 2+ ) or serve as cofactors (B1, B6, folate, and Zn 2+ ) in the metabolic pathways implicated in autism: neurotransmitter functions, DNA methylation, chromatin remodeling, transcriptional regulation, and neuronal development