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Based on nonclinical evidence, setmelanotide may re establish MC4 receptor pathway activity to reduce food intake and promote weight loss through decreased caloric intake and increased energy expenditure in patients with obesity due to acquired HO, BBS, or POMC, PCSK1, or LEPR deficiency associated with insufficient activation of the MC4 receptor

The potential for a placebo effect and the confounding influence of weight loss on PD symptoms also require careful consideration in interpreting results

Thats because diluting the urine in this fashion impacts the creatinine concentration

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