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Factors responsible for the liver's contribution to drug metabolism include that it is a large organ, that it is the first organ perfused by chemicals absorbed in the gut, and that there are very high concentrations of most drug-metabolizing enzyme systems relative to other organs

doi:10.14814/phy2.15577

Fishers exact test was employed, and the occurrence of false positives was corrected by the BenjaminiHochberg (B-H) multiple-test correction method

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