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23 The STEP-HFpEF and STEP-HFpEF-DM trials randomised patients with HFpEF and an LVEF 45% to oral semaglutide or placebo

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The compound's interaction with GABA receptors and nitric oxide signaling provides a protective effect against oxidative stress-induced neuronal damage

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The authors note that they determined depression based on a claims data algorithm

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