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These findings shed light on mechanisms underlying 5FU resistance and propose a rational strategy for combination therapy in CRC, emphasizing the potential clinical benefit of targeting mitochondrial metabolism to overcome resistance and enhance patient outcomes

Peer review Peer review information Nature Communications thanks Wei Du, Xiaoqing Tang, and the other anonymous reviewer(s) for their contribution to the peer review this work

Ipamorelin has been shown in some studies to enhance insulin sensitivity and glucose utilization through its growth hormone effects

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In conclusion, Ipamorelin offers a scientifically supported method for fat loss in women by boosting GH levels, accelerating metabolism, and reducing harmful visceral fat, all without increasing appetite