The Natural Medicines database (accessed January 2025) rates this combination as a "minor to moderate" interaction requiring monitoring rather than avoidance
doi: 10.1038/nature12721 208 GeierMSButlerRNGiffardPMHowarthGS
These factors included: having a sedentary lifestyle smoking eating a diet high in processed meat, dairy, and refined carbohydrates SSRIs may be less likely than older antidepressants, such as monoamine oxidase inhibitors and tricyclic antidepressants, to cause weight gain
Long-term or frequent use may increase the risk of: Dependence: Your body may start to rely on kratom products to feel normal
If itching is severe or occurs alongside hives or swelling, notify your prescriber immediately
Warning signs that should prompt a clinical evaluation include: memory loss that disrupts daily life, increased difficulty planning or problem-solving, confusion about time or place, difficulty completing familiar tasks, changes in mood or personality, and withdrawal from social activities
