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Activation of TRPV1 restored GPX4 levels, reduced lipid peroxidation, and improved cartilage integrity in both IL-1treated chondrocytes and OA mouse models (42)
doi: 10.1002/jps.2600520809, 31
Desarrollado a lo largo de cinco dcadas de investigacin por el Profesor Vladimir Khavinson y colegas del Instituto de Bioregulacin y Gerontologa de San Petersburgo , el Epithalon es un tetrapptido sinttico derivado de la epitalamina un extracto de polipptidos naturales de la glndula pineal
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10.1016/j.bios.2022.113978 112 ZhangQ
The ferroptosis activator RSL-3 and the PI3K/Akt pathway inhibitor LY294002 reversed Neuritins inhibitory effect on ferroptosis, indicating that Neuritin suppresses neuronal ferroptosis via PI3K/Akt pathway activation (Song et al., 2025)
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