Um, I would say if you wanted to play devil's advocate, the big thing is long-term safety, right
But it's the only way to ensure reliable, repeatable, and safe research outcomes
(Native, unmodified recombinant human IGF-1, sold as mecasermin/Increlex, is FDA-approved only for a narrow pediatric growth-failure indication and is chemically distinct from the LR3 analog.) In the US it is manufactured and sold almost exclusively as an unregulated "research chemical" labeled "not for human consumption," a labeling practice peptide vendors use to avoid marketing it as an unapproved drug
Absorption of biliary cobalamin in baboons following total gastrectomy
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Full tissue repair and functional recovery depend on the injury type and severity